Recommendation to Covid Vaccination

Much Ado about Nothing

The impact of COVID-19 vaccines on the pandemic will depend on several factors.  These include factors such as the effectiveness of the vaccines; how quickly they are approved, manufactured, and delivered; and how many people get vaccinated.

Most scientists anticipate that, like most other vaccines, COVID-19 vaccines will not be 100% effective. WHO is working to help ensure that any approved vaccines are as effective as possible, so they can have the greatest impact on the pandemic?

It’s too early to know if COVID-19 vaccines will provide long-term protection. Additional research is needed to answer this question. However, it’s encouraging that available data suggest that most people who recover from COVID-19 develop an immune response that provides at least some period of protection against reinfection – although we’re still learning how strong this protection is, and how long it lasts. But it has been observed that some populations are getting HERD immunity.

The way the morbidity and mortality has decreased in India, may be due to HERD immunity, Indians got due to mass exposure to the Virus as the Indians /Asians has innate immunity against the virus.

Some times I feel USA was right in not encouraging lockdowns, allowing the population to aquire Herd Immunity. These days Canadians are in panic mode and may prolong the sufferings of the people due to pandemic

Most COVID-19 vaccines being tested or reviewed now are using two dose regimensCurrently, there is no evidence that any existing vaccines will protect against COVID-19.However, scientists are studying whether some existing vaccines – such as the Bacille Calmette-Guérin (BCG) vaccine, which is used to prevent tuberculosis – are also effective for COVID-19.  WHO will evaluate evidence from these studies when available?

 As countries prepare for the implementation of their respective coronavirus disease 2019 (COVID-19) vaccination programs, the Strategic Advisory Group of Experts (SAGE) on Immunization of the World Health Organization (WHO) is undertaking a three-step process to provide guidance for overall program strategy as well as vaccine-specific recommendations

Step 1: A Values Framework. The WHO SAGE values framework for the allocation and prioritization of COVID-19 vaccination

 Step 2: Roadmap for prioritizing uses of Covid-19 vaccines (Prioritization Roadmap). The WHO SAGE Roadmap for prioritizing uses of COVID-19 vaccines in the context of limited supply

 Step 3: Evidence Framework (this document) to support development and issuing of vaccine-specific recommendations

Recommendation for use of vaccine is based upon

Criterion: Benefits & Harms of the Intervention

Criterion: Values & Preferences

Criterion: Resource Use

Criterion: Equity

Criterion: Acceptability

Criterion: Feasibility

Given the public health relevance of these vaccines, SAGE may nevertheless be required to issue policy recommendations based on indirect or incomplete data or on expert judgment where data are not yet available. The GRADE and evidence-to-recommendation tables will assist with transparently laying out the quality of data and the data gaps.

Various Vaccines    

Scientists around the world are developing many potential vaccines for COVID-19. These vaccines are all designed to teach the body’s immune system to safely recognize and block the virus that causes COVID-19.

Several different types of potential vaccines for COVID-19 are in development, including:

Inactivated or weakened virus vaccines, which use a form of the virus that has been inactivated or weakened so it doesn’t cause disease, but still generates an immune response.

Protein-based vaccines, which use harmless fragments of proteins or protein shells that mimic the COVID-19 virus to safely generate an immune response.

Viral vector vaccines, which use a virus that has been genetically engineered so that it can’t cause disease, but produces coronavirus proteins to safely, generate an immune response.

RNA and DNA vaccines, a cutting-edge approach that uses genetically engineered RNA or DNA to generate a protein that itself safely prompts an immune response.                      Vaccines Topics Four images working 01

The world is in the midst of a COVID-19 pandemic. As WHO and partners work together on the response — tracking the pandemic, advising on critical interventions, distributing vital medical supplies to those in need— they are racing to develop and deploy safe and effective vaccines. 

Vaccines save millions of lives each year. Vaccines work by training and preparing the body’s natural defenses — the immune system— to recognize and fight off the viruses and bacteria they target. If the body is exposed to those disease-causing germs later, the body is immediately ready to destroy them, preventing illness.

There are currently more than 50 COVID-19 vaccine candidates in trials. WHO is working in collaboration with scientists, business, and global health organizations through the ACT Accelerator to speed up the pandemic response? When a safe and effective vaccine is found, COVAX (led by WHO, GAVI and CEPI) will facilitate the equitable access and distribution of these vaccines to protect people in all countries. People most at risk will be prioritized. While we work towards rolling out a safe and effective vaccine fairly, we must continue the essential public health actions to suppress transmission and reduce mortality.